diisononyl phthalate sigma

2013. Reproductive and Behavioral Effects of Diisononyl Phthalate (DINP) in Perinatally Exposed Rats. Craig, Z. R. et al. Yang, X. et al. Isolated from rural domestic wastewater. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 32. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. CAS Characterization of Follicular Atresia Responsive to BPA in Zebrafish by Morphometric Analysis of Follicular Stage Progression. CASRN: 28553-12- and 68515-48-. Substitution of di(2-ethylhexyl) phthalate by di(isononyl) cyclohexane-1,2-dicarboxylate as a plasticizer for industrial vinyl plastisol formulations. Article Int. Finally, the authors are grateful to Drs. Samples for TUNEL and CAS3 techniques were fixed in Bouins solution (Bio-Optica) overnight, then rinsed in 70% EtOH and stored at 4C until needed for further analysis. MAPC and ALR planned the work. Oncol. Then, to block non-specific bindings, slide sections were treated with 40% calf serum (Sigma-Aldrich). Exp. Metab Brain Dis (2019) 34(1):23544. https://doi.org/10.1007/s00253-008-1548-5, Liu F, Liu Q, Zhang Y, Liu Y, Wan Y, Gao K, Huang Y, Xia W, Wang H, Shi Y, Huang Z, Lu B (2015) Molecularly imprinted nanofiber membranes enhanced biodegradation of trace bisphenol A by Pseudomonas aeruginosa. ALR supervised the whole experiments. Bogen, K. T. et al., Chronic Hazard Advisory Panel on Diisononyl Phthalate (DINP), U.S.C.P.S. J Hazard Mater 176:262268. Environmental exposure to the plasticizer 1,2-cyclohexane-dicarboxylic acid, diisononyl ester (DINCH) in US adults (2000-2012). Applied Microbiology and Biotechnology Hannon PR, Brannick KE, Wang W, Gupta RK, Flaws JA. In conclusion, our results provide a set of novel data on the dose-dependent effects of DiNP to the zebrafish ovary, suggesting that apoptotic biomarkers may be used as a relevant tool to evaluate the impacts of EDCs on the folliculogenesis of aquatic species. The genera of SSB-consortium were Serratia sp., Methylobacillus sp., Achromobacter sp., Pseudomonas sp., Stenotrophomonas sp., Methyloversatilis sp., Delftia sp. In a sample of young children (27-66 months old) attending German daycare centers, three DINCH metabolites were detected in virtually all of the spot urine samples. Pharmacol. 31(4), 284296 (2018). Gupta, R. C.) 637655 (Academic Press, San Diego, 2011). Nat Rev Mol Cell Biol (2007) 8:74152. Es wird sehr angenehme Musik aus den 70 und 80 Jahren gespielt. Biomonitoring Summary Di (isononyl) cyclohexane-1,2-dicarboxylate (DINCH) CAS No. Int J Hyg Environ Health (2007) 210(5):62334. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Biomed. Briefly, after dehydration in graded EtOH solutions, samples were clarified in xylene and embedded in paraffin. DINCH can also migrate into foods wrapped in plastic films or other food-contact materials. https://doi.org/10.1007/s00253-021-11255-5, DOI: https://doi.org/10.1007/s00253-021-11255-5. & Shepherd, D. M. Environmental immunology: lessons learned from exposure to a select panel of immunotoxicants. Similarly, rats exposed to 400 M of DEHP resulted in amplified mitochondria-ROS mediated apoptosis in granulosa cells and enhanced ovarian expression of apoptotic genes including baxa and cas3 (20). Chemosphere. The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice. 4601.M. For the general population, dietary sources have been considered the major exposure route, although DINCH has been measured in indoor air and dust (Fromme et al., 2016; Nagorka et al., 2011). Quantification of biomarkers of environmental exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) in urine via HPLC-MS/MS. Temperature and the concentration of the substrate are key factors for DINP biodegradation. https://doi.org/10.3390/ijms141224046, Jin D, Kong X, Li Y, Bai Z, Zhuang G, Zhuang X, Deng Y (2015) Biodegradation of di-n-butyl phthalate by Achromobacter sp. Environ Int (2017) 102:11424. Consumer Product Safety Commission. Diisononyl Phthalate (DINP) - Proposition 65 Warnings Website In this context, the caspase-dependent (CAS) pathway is among the main mechanisms driving apoptosis and programmed cell death in the ovary. Google Scholar. Di(2-Ethylhexyl) Phthalate Inhibits Antral Follicle Growth, Induces Atresia, and Inhibits Steroid Hormone Production in Cultured Mouse Antral Follicles. This includes: harm to minors, violence or threats, harassment or privacy invasion, impersonation or misrepresentation, fraud or phishing. DINP is one of the most commonly used plasticisers . Yang GCC, Wang CL, Chiu YH. Environ. 12:677853. doi: 10.3389/fendo.2021.677853. Oncotarget 8(57), 9768397692 (2017). PLoS One 13:e0204324. DINCH was not acutely toxic following high dose oral and dermal exposure in single large doses administered to animals (EFSA, 2006). doi: 10.1038/nrm2245, 27. Neurochemical Alterations Following the Exposure to Di-N-Butyl Phthalate in Rats. doi: 10.1038/nrm3735, 26. The data were analyzed with one-way ANOVA when fulfilled the conditions for applying a parametric test followed by Dunnetts post hoc analysis. After DiNP exposure, the autophagic gene coding for prkaa1 was the only upregulated marker, indicating possible metabolic stress (49), and further unfavorable physiological conditions. Perspect. The concentration range used was based on our previous studies (17, 18) and information from reported environmental concentrations of DiNP, ranging from 0.52 g L1 in European waters (27), 0.15 to 1.98 g L1 in European rivers (28), 21 and 70 g L1 in urban run-off (29), and 85 g L1 in urban storm-water (30). J Appl Polym Sci 2007;104:1215-20. Cookies used to make website functionality more relevant to you. 10(2), 327340 (2020). Mario G, Niso-Santano M, Baehrecke EH, Kroemer G. Self-Consumption: The Interplay of Autophagy and Apoptosis. Table2 Transcriptional effects of DiNP on the zebrafish ovary. Gastroenterol. Environ. Waterman, S. J. et al. Bioresour Technol 128:526532, Hines CJ, Hopf NB, Deddens JA, Silva MJ, Calafat AM (2012) Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations. We examined the effects of DiNP on the transcriptomic profile to unravel candidate markers for apoptosis, autophagy, and oxidative stress in the D. rerio ovaries. The Energy Sensing LKB1-AMPK Pathway Regulates p27kip1 Phosphorylation Mediating the Decision to Enter Autophagy or Apoptosis. Roles/writingoriginal draft: FG, OC, and HRH. Biosci. 3 Biotech 6:112. Fish Physiol Biochem (2018) 44(6):156176. Hormonal Regulation of Follicular Atresia in Teleost Fish. Food Chem. Next, endogenous peroxidases were inactivated using 3% H2O2 at RT for 5min. Health Perspect. Article Nat Rev Mol Cell Biol (2014) 15:8194. 140, 111275 (2020). Larsson K, Lindh CH, Jnsson BA, Giovanoulis G, Bibi M, Bottai M, et al. doi: 10.1016/j.tox.2006.10.005, 11. Oxidative Metabolites of Diisononyl Phthalate as Biomarkers for Human doi: 10.1016/j.envpol.2018.05.007, 18. Human exposure, hazard and risk of alternative plasticizers to phthalate esters. White, R. D. et al. If you are a resident of another country or region, please select the appropriate version of Tripadvisor for your country or region in the drop-down menu. Google Scholar. 25(2), 365376 (2012). Vol 20 Environ Sci Pollut Res (2013) 20:805776. S.T.B. Duan J, Deng T, Kang J, Chen M. DINP Aggravates Autoimmune Thyroid Disease Through Activation of the Akt/mTOR Pathway and Suppression of Autophagy in Wistar Rats. your institution, https://doi.org/10.1111/j.1529-8817.2010.00896.x, https://doi.org/10.1016/j.envpol.2020.115112, https://doi.org/10.1016/j.jhazmat.2015.05.004, https://doi.org/10.1016/j.reprotox.2019.12.006, https://doi.org/10.1016/j.ijhydene.2017.11.164, https://doi.org/10.1016/j.scitotenv.2017.10.298, https://doi.org/10.3390/microorganisms8010134, https://doi.org/10.1007/s11274-020-02850-1, https://doi.org/10.1007/s00420-011-0674-z, https://doi.org/10.1371/journal.pgen.1000255, https://doi.org/10.1016/j.jenvman.2016.05.072, https://doi.org/10.1016/j.envint.2016.09.013, https://doi.org/10.1016/j.ijheh.2006.11.008, https://doi.org/10.1371/journal.pone.0204324, https://doi.org/10.1016/j.chemosphere.2019.02.194, https://doi.org/10.1007/s00253-008-1548-5, https://doi.org/10.1016/j.cej.2014.10.046, https://doi.org/10.1016/j.jhazmat.2009.02.126, https://doi.org/10.1007/s13205-016-0524-5, https://doi.org/10.1007/s00284-008-9232-7, https://doi.org/10.1016/j.procbio.2012.02.027, https://doi.org/10.1371/journal.pone.0178213, https://doi.org/10.1016/j.jhazmat.2009.11.022, https://doi.org/10.1016/j.ibiod.2004.05.005, https://doi.org/10.1016/j.ibiod.2017.01.004, https://doi.org/10.1016/j.ibiod.2018.04.006, https://doi.org/10.1016/j.scitotenv.2016.03.171, https://doi.org/10.1016/j.scitotenv.2018.05.334. Sci. Man kann hier drinnen und auch drauen sitzen. Writingreview and editing: FG, IFP, OC, FLN, HRH, RM, BR. Int. 3, 312 (1973). Docket: EPA-HQ-OPPT-2018-0436. Subacute exposure to di-isononyl phthalate alters the morphology, endocrine function, and immune system in the colon of adult female mice, https://doi.org/10.1038/s41598-020-75882-0. European Commission. Appl Microbiol Biotechnol 102:10851096, Tang W, Zhang L, Fang Y, Zhou Y, Ye B (2016) Biodegradation of phthalate esters by newly isolated Rhizobium sp. Effects of Diisononyl Phthalate on Danio rerio Reproduction. January 6, 2010. In the case of zebrafish, low concentrations of BPA induce atresia by accelerating the vitellogenic phase III progression, resulting in abnormally enlarged phase IV follicles. The authors declare no competing interests. Commission, Editor. In this line, although we did not observe significant alterations in the transcripts of genes coding for autophagy (becn1, map1lc3c, mtor, uvrag, bid), any change in the proapoptotic factors could alter the homeostatic balance of follicular development and demise. Lee, B. M. & Koo, H. J. Hershberger assay for antiandrogenic effects of phthalates. (12/15/2015). Grande SW, Andrade AJM, Talsness CE, Grote K, Golombiewski A, Sterner-Kock A, et al. This number is based on the percentage of all Tripadvisor reviews for this product that have a bubble rating of 4 or higher. However, it should be noted that we used a heterologous polyclonal antibody raised against the cleaved form of human Caspase 3 (~17 kDa). Diisononyl phthalate (DINP) is one of plasticisers most employed in the production of plastic materials and belongs to the most important environmental contaminants. Biomonitoring Summary | CDC One of the reproductive mechanisms in female gonads is the follicular atresia, a process based on follicular reabsorption throughout an interplay between apoptosis and autophagy, ensuring reproductive viability of the follicles in the ovaries (21, 22), and also tightly regulated by hormones (23). The role of autophagy and apoptosis during follicular atresia depends on key molecular components that regulate each process (25). contracts here. Females (25 per group, in duplicate) were exposed for 21 days to three nominal concentrations of DiNP (Sigma-Aldrich; 99% purity): 0.42 g L1 (109 M); 4.2 g L1 (108 M); 42 g L1 (107 M) and a control (CTL) free of DiNP. Positive DNA fragmentation label (Figure2, red staining) was observed in follicular cells of atretic and vitellogenic follicles of zebrafish exposed to 0.42 g L1 (Figure2B) and 4.2 g L1 (Figure2C). 1. doi: 10.1007/s11356-013-1982-5, 5. Health Perspect. We here acknowledge that this may constitute a limitation of interpreting immunohistochemistry data since we cannot rule out the remote possibility of cross-reactivity with the pro-caspase 3 (37 kDa). Diisononyl Phthalate (DINP) Why am I being warned about potential exposure to DINP? https://doi.org/10.1016/j.chemosphere.2019.02.194, Liang DW, Zhang T, Fang HHP, He J (2008) Phthalates biodegradation in the environment. Water Res (2013) 47(3):131728. J. Toxicol. Reprod Fertil Dev (2013) 25(8):111525. Schutze A, Kolossa-Gehring M, Apel P, Bruning T, Koch HM. How is DINP used? PubMed Central In May 2023, Frontiers adopted a new reporting platform to be Counter 5 compliant, in line with industry standards. Can Insect-Based Diets Affect Zebrafish (Danio rerio) Reproduction? It is also toxic to the brain, reproductive system, liver, and . Available from: https://echa.europa.eu/documents/10162/31b4067e-de40-4044-93e8-9c9ff1960715. Kelly MA, Reid AM, Quinn-Hosey KM, Fogarty AM, Roche JJ, Brougham CA. Diisononyl phthalate (DINP) - Wiley Online Library Thank you for taking the time to confirm your preferences. PDF Diisononyl Phthalate (DINP) Reference List - U.S. Environmental Kinch CD, Ibhazehiebo K, Jeong JH, Habibi HR, Kurrasch DM. This number is based on the percentage of all Tripadvisor reviews for this product that have a bubble rating of 4 or higher. Scientific Reports (Sci Rep) The European Union has established a tolerable daily intake for DINCH at 1 mg/kg body weight per day (EFSA, 2006), Urinary levels of DINCH metabolites reflect recent exposure to DINCH. https://doi.org/10.1093/toxsci/kfz013, Article The gut as the largest endocrine organ in the body. Phthalates, Non-Phthalate Plasticizers and Bisphenols in Swedish Preschool Dust in Relation to Childrens Exposure. Protective effect of melatonin. Correspondence to Kreitinger, J. M., Beamer, C. A. Centers for Disease Control and Prevention. When data did not accomplish those conditions, Kruskal-Wallis non-parametric test was used. Zhao C, Jia Z, Li E, Zhao X, Han T, Tian J, et al. Manufacturer Request Granted: December 2019. Lyche, J. L. Chapter 48: Phthalates. Prot. Correspondence to Toxicology (2007) 229(12):11422. Diisononyl phthalate - Safety Data Sheet - ChemicalBook doi: 10.1016/j.scitotenv.2014.01.007, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. your institution. CAS Product identifier. Ahmadi E, Yousefzadeh S, Ansari M, Ghaffari HR (2017) Performance, kinetic, and biodegradation pathway evaluation of anaerobic fixed film fixed bed reactor in removing phthalic acid esters from wastewater. Toxicol. Am. PLoS ONE 7(4), e35538 (2012). Front. Division of Nutritional Sciences, College of Agricultural, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA, Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 S. Lincoln Avenue, Urbana, IL, 61802, USA, Department of Molecular and Integrative Physiology, College of Liberal Arts and Sciences, University of Illinois, Urbana, IL, USA, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana, IL, USA, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA, Romana A. Nowak,Wenyan Mei&Jodi A. Biodegradation of diisononyl phthalate by a consortium of - Springer doi: 10.1021/pr200840b, 52. Registration, Evaluations, Authorization, and Restriction of Chemical Substances (REACH). 395, 114981 (2020). Comp Biochem Physiol Part - C: Toxicol Pharmacol (2018) 213:718. more, Nuremberg Old Town and Nazi Party Rally Grounds Walking Tour in English, PRIVATE Nuremberg WW2 Combo Tour (Product code: 87669P15), Nuremberg Private Walking Tour: Old Town and Nazi Rally Grounds, PRIVATE Nuremberg Highlights Tour (Product code: 87669P12), Nuremberg WWII Tour, Courtroom 600 and 3rd Reich Sites, Nuremberg Old Town Walking Tour in English, Tour to Rothenburg ob der Tauber from Nuremberg in Spanish, Rothenburg ob der Tauber Private Walking Tour With A Professional Guide, Nuremberg Outdoor Escape Game: Medieval Darkness, No questions have been asked about this experience, Caymanbar, Gunzenhausen: Address, Caymanbar Review: 4/5. 94% of travelers recommend this experience. Toxicol. Adult female zebrafish (Danio rerio, AB wild-type strain, 1-year-old, 0.6 0.15g) were maintained in 100-L glass aquaria with oxygenated water under controlled conditions (28.0 0.5C; 14/10h of light/dark period). Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study. K.C. In the NHANES 2011-2012 survey period, MHNCH was detectable above 0.4 g/L at the 90th percentile in the total U.S. population, although children ages 6-19 years had detectable concentrations at the 75th percentile. Flaws, You can also search for this author in Nat Cell Biol (2007) 9(2):21824. Appl Microbiol Biotechnol 80:183198. Am. Exp. Results are summarized in Table2. doi: 10.1002/jmor.20554, 37. ZJUTW. Arch Toxicol 2013;87(5):799-806. A Toxicological Assessment of Endocrine Disrupting Chemicals Found in the BMW (Border, Midland and Western) Region of Ireland. Statistical significance was set at p < 0.05. The results are reported as mean standard error of the mean (SEM). Entering markets and bodies: increasing levels of the novel plasticizer Hexamoll DINCH in 24 h urine samples from the German Environmental Specimen Bank. J Proteome Res (2012) 11(2):113343. Both rows (genes) and columns (treatments) were grouped by hierarchical clustering. https://doi.org/10.1007/s13205-016-0524-5, Article The authors declare no competing interests. PubMed Central Sci Total Environ 541:9861001, Garca-Lpez R, Cornejo-Granados F, Lopez-Zavala AA, Snchez-Lpez F, Cota-Huzar A, Sotelo-Mundo RR, Guerrero A, Mendoza-Vargas A, Gmez-Gil B, Ochoa-Leyva A (2020) Doing more with less: a comparison of 16S hypervariable regions in search of defining the shrimp microbiota. 68, 247256 (2014). PubMed Central If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Foremost is the significance of the data obtained in zebrafish with DiNP to other aquatic species and other phthalate congeners exposure at it can occur due to the ubiquity of phthalates in aquatic ecosystems. J Phycol 46:11061113. doi: 10.1038/s41598-019-43436-8, 47. Relevant identified uses: For R&D use only.Not for medicinal, household or other use. They help us to know which pages are the most and least popular and see how visitors move around the site. In: The Fish Oocyte: From Basic Studies to Biotechnological Applications. EPA granted the manufacturer request for risk evaluation for di-isononyl phthalate . Product name : Diisononyl phthalate Product Number : 376663 Brand : Aldrich 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Inc. 3050 SPRUCE ST ST. & Ghia, J. E. Gut hormones: emerging role in immune activation and inflammation.
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