aloe vera for insulin resistance

2014;5(12):5293.Search in Google Scholar, 18 Moniruzzaman M, Rokeya B, Ahmed S, Bhowmik A, Khalil MI, Gan SH. 2019 Sep;241:111905.10.1016/j.jep.2019.111905Search in Google Scholar PubMed, 11 Regidor PA, Schindler AE, Lesoine B, Druckman R. Management of women with PCOS using myo-inositol and folic acid. An increase in progesterone leads to an increase in basal metabolism rate and may be the cause of weight loss. Network pharmacology-based analysis on bioactive anti-diabetic compounds in Potentilla discolor bunge. 2.3. PubMed J Reprod Infertil. Faghihi G, Iraji F, Abtahi-Naeini B, Saffar B, Saffaei A, Pourazizi M, et al. Efficacy of a novel fenugreek seed extract (Trigonella foenum-graecum, FurocystTM) in polycystic ovary syndrome (PCOS). 2019 Jun;9(6):215.10.3390/biom9060215Search in Google Scholar, 57 Sadrefozalayi S, Farokhi F. Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats. Accessibility Unable to load your collection due to an error, Unable to load your delegates due to an error. Phytother Res. Some factors appear to play an important in PCOS development including hypothalamicpituitary dysfunction, ovarian dysfunction, and increased insulin level [3]. 2019 Sep;241:111905. For long-term use, Ceylon cinnamon (true cinnamon) is preferred over cassia cinnamon, but both are effective. J Educ Health Promot. Furanocoumarins such as sphondin, xanthotoxin, and pimpinellin in the Heracleum persicum inhibits nitric oxide (NO) syntheses that reduced LH levels and estradiol release. 2014;211(5):487. e1-. In these various studies, aloe vera reduced fasting glucose levels by 46.6 mg/dL (2.6 mmol/l) and reduced HbA1c levels by an average 1.05%. "The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review". 7 Benefits of Aloe Vera For Diabetes (Science Backed) - Healthyy The Role of medicinal herbs in treatment of insulin resistance in 2002 Nov;72(2):199213.10.1016/S0024-3205(02)02173-2Search in Google Scholar, 48 Barzegari Firouzabadi F, Mirhosseini M. Effect of Persian hogweed (Heracleum persicum) on the morphological changes in mice testes and the level of hormone testosterone. Different doses of silymarin had positive effects such as a decrease in estradiol, testosterone, and LH and a significant increase in FSH and progesterone hormones due to the appearance of corpus luteum cysts in the ovary. 2006 Jan;13(1):638. Kort DH, Lobo RA. in Turkey investigated the effect of peppermint tea on the level of androgen in women with hirsutism. government site. Association between dietary intake of fatty acids and colorectal cancer, a case-control study. However, more side effects were observed in the metformin group compared to the cinnamon group. 2013;12(2):47581.Search in Google Scholar, 36 Swaroop A, Jaipuriar AS, Gupta SK, Bagchi M, Kumar P, Preuss HG, et al. Aloe vera is an insulin sensitizer and influence on pancreatic -cells [21]. J Steroid Biochem Mol Biol. Weight loss decreased fasting insulin levels and testosterone concentrations were significantly higher in the intervention group than the control group after 12 weeks of the intervention [30]. Green tea capsules or placebo for 3 months. Participants were randomly allocated to two groups. Talanta. PubMed, 5 Goodarzi MO, Carmina E, Azziz R. DHEA, DHEAS and PCOS. Animal Communication: When Im Calling You, Will You Answer Too? Adv Pharm Bull. Natural compounds from cinnamon have also shown potential for reducing insulin resistance and improving insulin sensitivity- two important factors of diabetes. Spearmint teas did not change testosterone and increase luteinizing hormone, follicle stimulating hormone, and estradiol. PubMed Reprod Biol Endocrinol. Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review. Are the biomedical sciences ready for synthetic biology? In addition, phytoestrogens inhibit progesterone metabolizing enzyme, 20-alpha-hydroxysteroid dehydrogenase and increase progesterone hormone. The intervention group received chamomile extract in different doses of 25 mg/kg, 50 mg/kg, and 75 mg/kg. Aloe Vera. Cinnamon supplementation improved significant reduction in fasting glucose and insulin resistance. The effect of metformin and cinnamon on serum anti-mullerian hormone in women having PCOS: A Double-blind, randomized, controlled trial. PubMed Central, 19 Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Catechin inhibits catechol-O-methyltransferase (COMT) which is responsible for reduction of norepinephrine. 2019 Jul;39(5):6528. 2016 Jul;106(1):615.10.1016/j.fertnstert.2016.05.003Search in Google Scholar 2014 Mar;4(2):1107. Biochem Biophys Res Commun. Aloe vera contains many compounds with different potential biological activities. Dietary aloe vera gel powder and extract inhibit azoxymethane - PubMed Mokaberinejad R, Rampisheh Z, Aliasl J, Akhtari E. The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial. Moreover, the hydroalcoholic extract of Heracleum persicum changes plasma sex hormone levels, inhibits folliculogenesis, and affects sexuality in women [50]. 2015 Jun;22(1):1622.Search in Google Scholar, 31 Tomatis V, Wassell S, Venables M, Walker C, Ray S, Siervo M, Griffin J, Bluck L. Effects of Green Tea and Coffee Polyphenols on Cardiometabolic Function in Women with Polycystic Ovary Syndrome. 2018 Nov;189:30814.10.1016/j.talanta.2018.07.012Search in Google Scholar, 62 Vickers NJ. Iran J Pharm Res. 2018 Feb;32(2):27683. 2018 Mar;34(2):/j/hmbci.2018.34.issue-2/hmbci-2017-0067/hmbci-2017-0067.xml.10.1515/hmbci-2017-0067Search in Google Scholar The intervention group had a significant decrease in fasting blood sugar (FBS) and insulin resistance. Medical herbs may be an important role in PCOS treatment. The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on DyslipidaemiaA Meta-analysis and Systematic Review. Avicenna J Phytomed. Avicenna Journal of Clinical Medicine. 2018 Feb;64(1):1224.10.1080/19396368.2017.1410591Search in Google Scholar We In another clinical trial, the intervention group received peppermint tea or chamomile tea twice a day for 30 days and covered one complete menstrual cycle. Farideh ZZ, Bagher M, Ashraf A, Akram A, Kazem M. Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. There was no change in fasting glucose, insulin sensitivity, and hormonal concentrations between the two groups [35]. 2017;24(156):42 8. 2017 Dec;7(4):6514.10.15171/apb.2017.078Search in Google Scholar, 56 Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to be Pregnant: A Randomized Clinical Trial. 2018 Feb;64(1):1224. Fenugreek has hypoglycemic effects through stimulating insulin synthesis, insulin secretion from beta-pancreatic cells, and inhibiting alpha-amylase and sucrose [35, 36]. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term. 2019 Jun;9(6):215.10.3390/biom9060215Search in Google Scholar After investigating the title and abstract, 221 articles were excluded from the study. Also, the -testosterone in the extract of Marrubium vulgare reduces LH. 2017 Jun;35(2). MEDICAL SCIENCES. Treatment groups have been increased serum concentrations of FSH, decrease LH and testosterone in treatment groups. 2012 Apr;4(2):10915. Aloe Vera Benefits: 16 For Skin, Body, Hair and More - Women's Health 2011 Mar;9(1):39.10.1186/1477-7827-9-39Search in Google Scholar Fenugreek has anti-diabetic and cholesterol-lowering effects and decreases insulin resistance in women with PCOS [35]. The palmitic acid -oxidation has anti-androgenic effects. The Role of medicinal herbs in treatment of insulin resistance in But the androgen levels and the insulin resistance had no significant changes between the two groups [23]. PubMed Central, 17 Radha M, Padamnabhi N, Laxmipriya N. Evaluation of Aloe barbadensis mill. J Integr Med. Fertil Steril. Is Aloe Juice Good for Diabetes? - EatingWell 2018;27(3):55663. The FASEB Journal. Polycystic ovaries and herbal remedies: A systematic review. The current research was performed using the terms of medical subject headings and combinations of the keywords using the following search strategy: polycystic ovary syndrome or PCOS and medical herbs or herb or antioxidant or nutrition or ovarian cysts or hyperandrogenism or hirsutism or botanical medicine, or insulin resistance. PubMed, 7 Hopkinson ZE, Sattar N, Fleming R, Greer IA. Integr Med Res. Moini Jazani A, Nasimi Doost Azgomi H, Nasimi Doost Azgomi A, Nasimi Doost Azgomi R. Daru. In vitro antioxidant effects of Aloe barbadensis Miller extracts and the potential role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats. The observed changes in biomarkers suggest metabolic benefits. J Soc Gynecol Investig. Capsule containing fennel (150 mg/kg) (100 mg/kg) and metformin (100 mg/kg), 63 days + 40 female rats were divided into five (group 1: control; Group 2: estradiol valerate; Group 3: PCOS + fennel received 150 mg/kg; Group 4: PCOS + fennel 2 group received fennel (100 mg/kg); Group 5: PCOS + metformin consumed metformin (100 mg/kg), Capsule containing 250, 500, and 1000 mg/kg fennel extract, 10 days + 30 rats case and 6 rats were considered as control. 1500 mg metformin divided into two doses or 100 mg DLBS3233 (including cinnamon) for 6 months, 6 months + 20 received metformin, and 18 patients received. 2015 Jan;145:21325.10.1016/j.jsbmb.2014.06.003Search in Google Scholar Nutrition. investigated the effect of cinnamon extract on insulin resistance in patients with PCOS. Experimental group orally received doses of 500 mg/kg and 1000 mg/kg for 21 days. Type 2, in which insulin is usually produced, but the individuals develop a kind of insulin resistance [2]. PubMed Central, 34 Mombaini E, Jafarirad S, Husain D, Haghighizadeh MH, Padfar P. The impact of green tea supplementation on anthropometric indices and inflammatory cytokines in women with Polycystic Ovary Syndrome. The intervention group was treated by cinnamon powder capsules 1.5 g/day in 3 divided doses for 3 months and the control group received a placebo. Moniruzzaman M, Rokeya B, Ahmed S, Bhowmik A, Khalil MI, Gan SH. 2018 Sep;131(17):21123.10.4103/0366-6999.239309Search in Google Scholar The quality of the studies was independently assessed by 2 persons (SD and MGh), and if two assessors do not agree with each other, the assessment was completed as a discussion with a third person (SAMJ). 2023 Apr 21;9(5):e15488. 2012 Apr;4(2):10915.10.4103/0974-8490.94736Search in Google Scholar Silymarin reduced inflammation and collagen in the follicular sheath and eventually reduced the layer thickness [37, 38]. Int J Pharm Sci Res. Association of dietary antioxidant index with body mass index in adolescents. Results Overall, 361 records were identified through database searching. Some studies reported that Type-A polymers and procyanidine polyphenols in the cinnamon extract enhance insulin signaling at the post-receptor level, increase the activity of Phosphoinositide 3 (PI3) kinase, increase the glucose uptake via enhancing the GLUT4 glucose transporter, inhibit the glycogen synthesis, and enhance glycogen synthesis and hypoglycemic effects [22, 23]. Effect of Aloe Vera Whole Leaf Extract on Blood Glucose Insulin resistance impairs glucose disposal, causing an increase in endogenous insulin production to compensate. The LH and FSH levels increased and ovarian volume, cyst size, and the number of ovarian cysts decreased. . 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Fasting insulin, LDL-C, and insulin resistance were reduced after 12 weeks in intervention group compared with control group. J Soc Gynecol Investig. Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer. Green tea extract enhanced the follicles and corpus luteum, and reduced cystic follicles in the ovary [32]. Shahid Beheshti University of Medical Sciences. Numerous research studies have found Aloe Vera to be effective in preventing diabetes. Silymarin has anti-angiogenesis effects which reduce proliferation of follicular cells, thereby reducing the production of testosterone, and increases in corpus luteum due to increasing progesterone hormone [37]. Aloe Uses, Benefits & Dosage - Drugs.com Herbal Database Gavari A, Vladi J, Ambrus R, Joki S, Szab-Rvsz P, Tomi M, et al. Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. 2014;24(2):7480. Benzodiazepine joined to gamma aminobutyric acid (GABA) is a natural neurotransmitter amino acid in brain and reduces the secretion of LH [44]. Cinnamon Cinnamomum is an herbaceous plant belonging to Hassanzadeh et al. Elsevier; 2016. Marx TL, Mehta AE. Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. Weight lost, decrease in fasting insulin, and level of free testosterone. J Hum Reprod Sci. Trigonella foenum- graecum seed extract 500 mg/day, 90 days + 50 premenopausal women with PCOS. J Reprod Infertil. Mokhtari M, Ebrahimpoor MR, Harfsheno S. The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome. Pharmacological Update Properties of Aloe Vera and its Major - PubMed PMID: 32183224 PMCID: PMC7144722 DOI: 10.3390/molecules25061324 Abstract Aloe verahas been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Prospects of Aloe vera and its Bioactive Compounds in Diabetes Kerempour et al. 2018 Jun;500(3):797803.10.1016/j.bbrc.2018.04.162Search in Google Scholar A study by Chan et al. Syiem D, Syngai G, Khup PZ, Khongwir BS, Kharbuli B, Kayang H. Hypoglycemic effects of Potentilla fulgens L in normal and alloxan-induced diabetic mice. 2009 Jul;124(3):47580.10.1016/j.jep.2009.05.012Search in Google Scholar 2007 May;21(5):4447.10.1002/ptr.2074Search in Google Scholar The results of the studies showed that peppermint tea caused a significant decrease in testosterone levels and an increase in LH and FSH levels. Potentillas increases the number of follicles and reduces the number of ovarian cysts. Ashkar F, Rezaei S, Salahshoornezhad S, Vahid F, Gholamalizadeh M, Dahka S, Doaei S. The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. In this study, silymarin was administered to rats at doses of 20 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg, and 300 mg/kg for 14 days [38]. Aloe vera (Aloe barbadensis Miller) is a plant that has anti-diabetic and anti-hypercholesterolemic function. PubMed Central, 70 Mokhtari M, Ebrahimpoor MR, Harfsheno S. The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome. (HDL) ratio after oral supplementation with Aloe vera in mice. Serum total antioxidant capacity significantly increased and malondialdehyde decreased in intervention group. Treatment of polycystic ovary syndrome with spironolactone plus licorice. Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology. J Hum Nutr Diet. PubMed Central, 8 Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. 2017 Dec;7(4):6514. 11 (Issue 1), pp. J Hum Reprod Sci. J Ethnopharmacol. The control group received 0.1 ml sesame oil and 100 L 0.5% methylcellulose+ the DHEA group received 6 mg/100 g body weight dissolved in 0.1 ml of sesame oil and the DHEA + cinnamon group received 10 mg/100 g body weight mixed in 100 L 0.5% methylcellulose, 20 days + the animal randomly divided into 3 groups (control group (n=10), DHEA group (n=25), DHEA + cinnamon group (n=25)). 2015;2015.10.1155/2015/659041Search in Google Scholar The results indicate that some medicinal herbs may have a key role in treating PCOS. Cinnamon. Licorice reduces excess hair growth due to enzymatic effects on the melatonin production cycle and possibly inhibits tyrosinase activity [66, 67]. In this study, 340 Chinese obese women with PCOS were randomly divided into the intervention and placebo groups. 2002 Nov;83(1-2):5561. Molecules. PubMed PubMed Central, 3 Mohseni Kouchesfahani H, Nabyooni M, Adham H. Investigating the therapeutic effect of eee venom on polycystic ovarian syndrome in rats. Mentha (peppermint) is a medicinal plant of the Lamiaceae family. 2022 Dec 22;13(6):2406-2419. doi: 10.1093/advances/nmac101. The compounds of herbal medicine can affect lipid profiles, insulin resistance, blood glucose, the serum levels of hormones, and the ovarian tissue. Iran J Pharm Res. Sex hormone-binding globulin (SHBG) is a glycoprotein that can regulate the bioavailability of sex steroid hormone and SHBG levels are correlated with the risk of PCOS. Animal Communication: When Im Calling You, Will You Answer Too? 2017 Nov;31(11):163550. In this study, Foeniculum vulgare was injected intraperitoneally in different doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg for 10 days. PCOS has been divided into 3 phenotypes that include Classic PCOS (Phenotypes A and B), Ovulatory PCOS (Phenotype C), and Nonhyperandrogenic PCOS (Phenotype D) [8]. The main characteristics of the studies are presented in table 1. J Endocrinol Invest. Alkan EE, Celik I. Additionally, 102 articles were excluded after studying the full text of the articles, and finally 38 eligible articles were identified and included in the review study. There were no differences in any of the hormone levels measured in either group. 2017 Mar;15(2):95101. PubMed, 67 Faghihi G, Iraji F, Abtahi-Naeini B, Saffar B, Saffaei A, Pourazizi M, et al. Hydroalcoholic extract of chamomile also contains ascorbic acid to prevent weight gain and reduce cholesterol levels [46]. Foeniculum vulga extract does not change creatinine level but decreases urea. found that licorice extract inhibits the symptoms of PCOS by regulating controlling levels of serum FSH, LH/FSH ratio, and irregular ovarian follicles [69]. 2015;8(5). Green tea in tablet produced by DINEH IRAN, 12 weeks + 60 overweight women suffering from PCOS (30 received green tea and 30 placebo). J Nutr Sci. Nevertheless, Aloe gel has been reported to increase glucose levels in tetraoxane-induced diabetic rats. J Ethnopharmacol. Ashkar F, Rezaei S, Salahshoornezhad S, Vahid F, Gholamalizadeh M, Dahka SM, Doaei S. Biomol Concepts. A clinical trial examined the endocrine effects of 1 mL of Aloe vera gel for 45 days in rats; as a result, Aloe vera did not change the biomarker enzymes and weight but improved the insulin sensitivity and 3HSD and 17HSD activity [18]. J Endocrinol Invest. 2015. 2018 Nov;59(11):56771.10.11622/smedj.2018135Search in Google Scholar Regidor PA, Schindler AE, Lesoine B, Druckman R. Management of women with PCOS using myo-inositol and folic acid. We excluded studies unrelated to the PCOS and medical herbs. Aloe vera phytosterols such as sitosterol reduce serum cholesterol levels and normalized (3-Hydroxysteroid dehydrogenase) 3HSD activity in PCOS rats [15, 17, 18]. doi: 10.1002/edm2.367. Cleve Clin J Med. Aloe vera in diabetic dyslipidemia: Improving blood glucose and Arch Gynecol Obstet. in 2014 investigated the effect of silymarin on PCOS induced by estradiol valerate in rats. Fenugreek extracts have soluble fibers which decrease blood sugar by reducing enzymatic digestion and absorption of carbohydrates, thus decreasing post-prandial glucose levels [35, 36]. The intervention group received 500 mg/kg and 1000 mg/kg. 2007 Jul;88(1):2403. PubMed, 6 Deswal R, Yadav A, Dang AS. Yang et al. Goodarzi MO, Carmina E, Azziz R. DHEA, DHEAS and PCOS. Green tea inhibited testosterone production and stimulation, reduced LH level, diastolic blood pressure, body and ovarian weight. 2007 Mar;131(1):617. The effect of cinnamon on polycystic ovary syndrome in a mouse model. Body weight (P = 0.02), body fat mass (p = 0.03) and insulin resistance were significantly lower in the intervention group. More side effects were observed in the metformin group compare with cinnamon group. Exploring the effect of green tea on weight loss and serum hormone levels in overweight and obese patients with polycystic ovary syndrome. Some flavonoids, such as apigenin, competitively inhibit the binding of flunitrazpam, thereby reduce the secretion of LH [44, 70, 71]. 2015;14(4):121533.Search in Google Scholar, 33 Tehrani HG, Allahdadian M, Zarre F, Ranjbar H, Allahdadian F. Effect of green tea on metabolic and hormonal aspect of polycystic ovarian syndrome in overweight and obese women suffering from polycystic ovarian syndrome: A clinical trial. Barzegari Firouzabadi F, Mirhosseini M. Effect of Persian hogweed (Heracleum persicum) on the morphological changes in mice testes and the level of hormone testosterone. 2017 Mar;15(2):95101.10.1016/S2095-4964(17)60320-0Search in Google Scholar, 14 Desai BN, Maharjan RH, Nampoothiri LP. 2015;20(1):31-42Search in Google Scholar, 52 Alkan EE, Celik I. Adib-Hajbaghery M, Mousavi SN. Chamomile tea significantly decreased HbA1C and serum insulin levels (p < 0.001), homeostatic no significant changes were reported in serum HDL. Chamomile contains phytoestrogen which can decrease the menstrual disorder through changes in hormone positive estrogen feedback [45]. Kim K, Chung MH, Park S, Cha J, Baek JH, Lee SY, et al. Bookshelf and transmitted securely. Jalili V, Poorahmadi Z, Hasanpour Ardekanizadeh N, Gholamalizadeh M, Ajami M, Houshiarrad A, Hajipour A, Shafie F, Alizadeh A, Mokhtari Z, Shafaei H, Esmaeili M, Doaei S. Endocrinol Diabetes Metab. Changes in lowdensity lipoprotein cholesterol level, highdensity lipoprotein cholesterol, and triglycerides were not significant. Jelodar G, Askari K. Effect of hydroalcoholic extract of Vitex agnus-castus fruit on fertility and estrous cycle in letrozole-induced polycystic ovary (PCOS) in rat. 2015;8(5).Search in Google Scholar, 60 Mokaberinejad R, Rampisheh Z, Aliasl J, Akhtari E. The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial. 2023 Mar 30;27(1):85-91. doi: 10.5935/1518-0557.20220024. 2018 Sep;7(3):26470. The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. Abdollahi S, Hasanpour Ardekanizadeh N, Poorhosseini SM, Gholamalizadeh M, Roumi Z, Goodarzi MO, Doaei S. Adv Nutr. https://doi.org/10.4067/S0717-9502201700020005410.4067/S0717-95022017000200054Search in Google Scholar, 38 Nabiuni M, Kayedpoor P, Mohammadi S, Karimzadeh L. Effect of silymarin on estradiol valerate- induced polycystic ovary syndrome. A study by Zanganeh et al. Lua AC, How CH, King TF. Aloe vera (AV), which . PubMed Central, 13 Ma QW, Tan Y. 2012 Nov;17(11):1285167. This study aimed to assess the effects of natural antioxidants and herbal substances on PCOS-IR by a systematic review in in patients with PCOS. 2018 Apr;34(4):2727. 31 The anti-diabetic effect of processed Aloe gel was also studied in diet-induced obesity (DIO) mice, which is an animal model with metabolic abnormalities that are very similar to non-insulin-dependent human DM, including hyperglycemia . Silybum marianum decreased low-density lipoprotein, cholesterol, and plasma glucose levels [39]. J Integr Med. in 2006 in Hong Kong aimed to investigate the effects of Chinese green tea on weight and biochemical and hormonal profiles in obese patients with PCOS. Asia Pac J Clin Nutr. In another study, subjects received 370 mg of oral capsules of chamomile for 3 months; the level of testosterone decreased.
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