Li Y, Ligr M, McCarron JP, et al. 2013;41:74364. Qing Dai (Indigo Naturalis, ) - The Herb Depot Under the action of microorganisms, indole glycosides and endogenous polyglucosidases are released from stems and leaves. Compared with ATRA therapy, there was no significant difference in blood parameters [8, 75]. Patients randomized to 200 mcg/g of indirubin had the greatest improvement in PASI scores (69.2%; 95% CI, 55% to 82.8%), followed by the 100 mcg/g group (63.1%; 95% CI, 52.8% to 73.5%), the 10 mcg/g group (53.4%; 95% CI, 42.8% to 64%), and the 50 mcg/g group (50.3%; 95% CI, 37.4% to 63.2%) (between-group comparison of P=0.0445). 2018;93:146773. Br J Haematol. 2017;52:90419. Another study found that indirubin can also reduce crypt deformation and mucosal damage, and reduce the infiltration of inflammatory cell in colonic mucosa [33]. Exp Ther Med. Google Scholar. Hutchinson EC. PubMed Central React Oxyg Species (Apex). Oseltamivir and zanamivir are commonly used neuraminidase inhibitors, which commonly used to prevent and treat influenza. It may also cause colitis and pulmonary arterial hypertension. Chin J Integr Tradit West Med on Digest. 2017;2017:3082805. Int Arch Allergy Immunol. Another study found that indigo and indirubin could promote clearing of ROS, reduce the malondialdehyde content, promote the balance between the antioxidant system and ROS, inhibit lipid peroxidation, and protect cell membranes from oxidative damage [21]. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. "Stasiak 2014 Before the development of synthetic aniline and indigo dyes, indigo plants were grown commercially in the East Indies, South America, and Central America. Chiang YR, Li A, Leu YL, et al. Pro Anat Sci. The authors declare no competing financial interests. People can use certain treatments, home remedies, and lifestyle changes to prevent psoriasis flare-ups. This method can accurately and rapidly determine the content of heavy metals mentioned above. Tryptanthrin can make the murine myeloid leukemia WEHI-3B JCS cells stay in G0/G1 phase, and down-regulate the expression of cyclin D2, D3, CDK2, 4, 6 genes, so as to inhibit the proliferation of WEHI-3B JCS and play an anti-tumor role [58]. Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. We searched PubMed, web of science, CNKI, Google academic, Elsevier and other databases with the key words of Indigo naturalis, and reviewed and sorted out the modern research of indigo naturalis based on our research results. Isatis: Uses, Side Effects, Dose, Health Benefits - eMedicineHealth The manufacturing process of Indigo naturalis. J Pharmacol Sci. The best quality is fine powder, blue in color, light and loose in texture, with no sand and stone. The efficacy and safety of topically applied indigo naturalis - PubMed Indigo naturalis has clear antiviral activity, as dose Radix Isatidis [13]. 1 lb authentic, natural Qing Dai in bulk herb (sealed bag) Common names: Indigo, Natural Indigo Scientific name: Indigo Naturalis. Indigo was a popular dye during the Middle Ages.Simon 1984, Stasiak 2014 Indigo naturalis is thought to alleviate pain and have antipyretic, anti-inflammatory, antiviral, antimicrobial, antitumor, and detoxifying properties. Zhu HH, Wu DP, Du X, et al. Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Indigo naturalis is a Chinese herbal medicine that has currently been used to treat various inflammatory diseases, including ulcerative colitis. The organic components can be divided into the following categories [6, 9, 10]. CAS Rapid and Integrated Quality Assessment of Organic-Inorganic Composite Herbs by FTIR Spectroscopy-Global Chemical Fingerprints Identification and Multiple Marker Components Quantification of Indigo Naturalis (Qing Dai). PubMed Lin YK, See LC, Huang YH, et al. Patients were instructed to apply 1 to 2 drops of Lindioil to one hand and 1 to 2 drops of calcipotriol to the other hand twice daily for 24 weeks. 2020;142:14856. Mahonia aquifolium is a flowering plant that comes from the mahonia shrub. At present, thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) are the most commonly used quality control methods for indigo naturalis. Dermatology. To increase its clinical effect, indigo naturalis is usually used in combination with other Chinese herbs, such as Gypsum Fibrosum, Bezoar, Snakegourd Seed and Radix Bupleuri. Exploring the Mechanism of Indigo Naturalis in the Treatment of Huang SL, Xiang GA, Wang Y, Lin HX, Fu XBL. 2010;42:5005. Our group's previous studies 1,2 have shown that topical application of indigo naturalis significantly improves psoriatic symptoms. 2017;40:112. Indigo naturalis, as traditional Chinese medicine, has been widely used in autoimmune diseases and inflammatory diseases, such as psoriasisand allergic contact dermatitis [46, 47]. Influenza Virus. Today, almost all indigo used commercially is produced synthetically. Available for Android and iOS devices. It was found that liver aspartate aminotransferase or alanine aminotransferase concentration increased in 9% patients with RIF plus ATRA and 6% patients with arsenic trioxide plus ATRA, and grade 23 infection occurred in 14% patients with RIF plus ATRA and 23% patients with arsenic trioxide plus ATRA. Topical indigo naturalis may cause pruritus, rash, erythema, and nasopharyngitis. Chan HL, Yip HY, Mak NK, et al. Molecules. Aim of review (2016, August). And this inhibitory effect was also observed as well as influenza virus B/Lee-infected cells [44]. 7 8 IN is an extract derived from stems and leaves of several plant species including Baphicacanthus cusia (Nees) Bremek of the Acanthacaea family, with indigo and indirubin considered its main organic ingredients. Multicenter randomized trial of arsenic trioxide and Realgar-Indigo naturalis formula in pediatric patients with acute promyelocytic leukemia: Interim results of the SCCLG-APL clinical study. 2020;10:366. 2017;8:10561529. 2011;42:545. Psoriasis is a chronic immune related skin disease. Simultaneously, Ca(OH)2 in lime reacts with CO32 in the soaking solution to form the CaCO3 nucleus, which provides carriers for adsorbing indigo, indirubin and other compounds. Chin J Hematol, 2006: 8014. Oral arsenic plus retinoic acid versus intravenous arsenic plus retinoic acid for non-high-risk acute promyelocytic leukaemia: a non-inferiority, randomised phase 3 trial. The NCCIH state that there is some evidence that Aloe vera could help with psoriasis, though less evidence than for Mahonia aquifolium and indigo naturalis. Wang L, Zhou GB, Liu P, et al. J Cancer Res Clin Oncol. It has very good clinical effect on psoriasis, leukemia and ulcerative colitis. 2006;281:2342535. Indigo naturalis (IN), which is derived from indigo plants such as Strobilanthes cusia (Nees) Kuntze, Persicaria tinctoria (Aiton) Spach, and Isatis tinctoria L., has been traditionally used in the treatment of hemoptysis, epistaxis, chest pain, aphtha, and infantile convulsion in China for thousands of years. At present, researches on the quality control of indigo naturalis are mainly focused on the organic compounds such as indigo, indirubin and tryptamine. The good news is using indigo powder for your hair can prevent hair fall. Indigo naturalis also can be used to cure oral diseases, such as a swollen, sore throat, ulcers, swelling, pain, and rottenness of mouth and tongue. Lin YK, Leu YL, Huang TH, et al. Lipid peroxidation product 4-hydroxy-2-nonenal, Formyl-L-methionyl-L-leucyl-L-phenylalanine. 2004;67:16774. Herbs for psoriasis: Which herbal remedies are best? - Medical News Today ), against Helicobacter pylori-infected Mongolian gerbils. Gill H, Yim R, Lee HKK, et al. Itshould be noted that in a clinical report, 4 out of 42 subjects had pruritus after using indigo naturalis ointment [81]. People can buy indigo naturalis at health stores or online. The indigo content was more than 2% and that of indirubin was more than 0.13%. Data sources include IBM Watson Micromedex (updated 14 May 2023), Cerner Multum (updated 28 May 2023), ASHP (updated 10 Apr 2023) and others. Biochem Biophys Res Commun. Pediatr Dermatol. (Chang 2015), In vitro analysis demonstrates that indigo down-regulates IL-17 and its pathway genes. The reaction mechanism of indigo and indirubin. 1). Wang L, Li X, Liu X, et al. Recent clinical trials suggest that the treatment can help with psoriasis, and a systematic review from 2015 found that, along with Mahonia aquifolium, indigo naturalis was an effective herbal remedy for psoriasis. Airbus nears 500-jet order from India's IndiGo: Sources PubMedGoogle Scholar. The raw materials used to make indigo naturalis are natural plant extracts, which are not only 100% natural but also meet international standards. J Mol Med (Berl). Indigo can protect gastric mucosa from ethanol-induced gastric injury by preventing ethanol-induced DNA damage through non-enzymatic antioxidation and inhibition of polynuclear neutrophil infiltration [22]. Indigo Uses, Benefits & Dosage - Drugs.com Herbal Database Eisenbrand G, Hippe F, Jakobs S, et al. CAS Stahl M, Tallman MS. Differentiation syndrome in acute promyelocytic leukaemia. The voucher specimen of Indigo Naturalis (DFC-LF-201509) was deposited in Department of Natural Medicine, School of . No treatment-related adverse effects were observed. In addition to the treatment of leukemia, psoriasis and colitis, modern research has found that indigo naturalis can also be used to treat liver injury, nephritis, mouth ulcer and other skin diseases, which may be related to its anti-inflammatory, antioxidant and immune regulatory effects [18, 20, 92, 93]. The complete remission rate of APL patients with Realgar-indigo naturalis was 96.798%, and the 5-year overall survival rate was 86.88% [54, 55]. Research on Application of Qingdai (Natural Indigo) in History. Efficacy of Indigo Naturalis Therapy for Ulcerative Colitis: A Case Series. 2010;115:16906. 2017;173:2333. Complementary and alternative medicine for psoriasis: What the dermatologist needs to know [Abstract]. This is only a brief summary of general information about this product. Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. The antimicrobial assays in vitro suggested that the ethyl acetate extract of indigo naturalis could remarkably inhibit gram-positive bacteria (methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus aureus) and mildly inhibit noncutaneous fungal pathogens of onychomycosis (Aspergillus fumigatus and Candida albicans) [38]. YQY, XCG, and HL designed the study; ZT, DX, HYN and HSJ collected and analyzed the data; YQY, ZT, and HYN wrote the paper. Mak NK, Leung CY, Wei XY, et al. (Saito 2015), In a randomized, double-blind, placebo-controlled clinical trial in 86 Japanese patients with active ulcerative colitis, the effect of indigo naturalis on clinical response was assessed.
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